SOX11

Background

SOX11 is a nuclear transcription factor, which is mainly related to embryonic neural development. It mainly contains two functional regions, the HMG DNA binding region at the N-terminal and the trans activation region at the C-terminal. The SOX11 is very important for embryonic nervous system and tissue reconstruction. It has normal expression in the development of human embryonic nervous system, and it is necessary for the growth of neural process and the existence of neurons. In 18-25 week fetal tissues, SOX11 is mainly expressed in the brain. In addition to the central nervous system, SOX11 is expressed at the junction of epithelium and mesothelial tissue, but not in normal adult tissues. SOX11 is overexpressed in most mantle cell lymphomas.