DOG1

Background

DOG1 is a calcium dependent chloride channel protein encoded by TMEM16A gene, which is located on chromosome 11q13. DOG1 has the function of regulating cholinergic activity of gastrointestinal smooth muscle and cell survival and proliferation. More than 90% of gastrointestinal stromal tumors (GISTs) were DOG1 positive. The staining is located in the cytoplasm and cell membrane, showing diffuse dense strong staining. DOG1 and CD117 can be used as important indexes in GIST identification. The sensitivity and specificity of dog1 are higher than that of CD117. DOG1 is also used in the identification of salivary adenocarcinoma, pancreatic cancer and renal cancer.