EGFR

Background

Epidermal Growth Factor Receptor antibody (EGFR) is a transmembrane glycoprotein receptor tyrosine kinase and is activated by EGF. It is overexpressed or mutated in many tumors and controls tumor growth through signal transduction, and is closely related to neovascularization, tumor invasion and metastasis.Various studies have observed and reported over-expression of EGFR in tumors of breast (25%), brain, bladder, lung, gastric, esophagus, cervix, ovary and endometrium. At present, it is a reference for targeted therapy of lung non-small cell carcinoma.