MSH2

Background

DNA mismatch repair (MMR) system is composed of enzyme molecules that specifically repair DNA base mismatch. The existence of this system can ensure the integrity and stability of genetic material, avoid the mutation of genetic material, and ensure the high fidelity of DNA replication. It is composed of hMLH1, hMSH2, hpms1, hPMS2 and other genes. HMSH2 is located in human chromosome 2p21-22, encoding a protein composed of 934 aa. The mutation of hMSH2 gene occurs in sporadic colorectal cancer. The mutation of microsatellite hMSH2 gene is related to 50% of familial and non-familial polyposis colorectal cancer (HNPCC).