Napsin A

Background

Napsin is a kind of gastric enzyme like aspartate protease. There are two related Napsin: Napsin A and Napsin B. Napsin A is a single chain protein with molecular weight close to 38 kDa.It is highly expressed in human lung and kidney, but low in spleen. Napsin A is expressed lung type II epithelium and lung adenocarcinoma. The expression sensitivity of Napsin A in lung adenocarcinoma is significantly higher than SP-A and SP-B, and it has very high specificity. In some cases of poorly differentiated lung adenocarcinoma without TTF-1, but Napsin A is expressed.Napsin A Monoclonal antibody is recommended to be used in combination with TTF-1 for the differentiation of primary lung adenocarcinoma and other tissue-derived adenocarcinoma.