p120
Product Information
Cat:PA6752
Clone NO:YN01266m
Application:IHC-P
Positive cellular localization: cell membrane/Cytoplasm
Reactivity: Human
Host: Mouse
Background
The linker family includes α - Catenin, β - Catenin, r-catenin and p120 catenin. P120 catenin is linked to E-cadherin in the cytoplasm near the cell membrane, forming a complex, which is stable and closely linked. If E-cadherin is absent, p120 catenin will accumulate in the cytoplasm. There is only a small amount of membrane expression in breast ductal carcinoma, but there is no p120 catenin accumulation in the cytoplasm. The antibody can be used to differentiate breast lobular / ductal tumors.
Formalin-fixed, paraffin-embedded (FFPE) Human Breast Cancer tissue with p120 Monoclonal Antibody.