SDHB

Product Information
  • Cat:PA7212

  • Clone NO:YN02535r

  • Application:IHC-P

  • Positive cellular localization: Cytoplasm

  • Reactivity: Human

  • Host: Rabbit

Background

Succinate dehydrogenase (SDH) complex is a key respiratory enzyme composed of four subunits: SDHA, SDHB, SDHC and SDHD. Normal cells generally express SDHB in plasma, while abnormal cells lack SDHB expression.SDHB mutation can lead to tumors in chromaffin cells, causing a class of tumors called succinate dehydrogenase deficiency, including hereditary paraganglioma and hereditary pheochromocytoma, succinate dehydrogenase deficient renal cell carcinoma and succinate dehydrogenase deficient gastrointestinal stromal tumor (GIST).

Pathological Antibodies