SDHB
Product Information
Cat:PA7212
Clone NO:YN02535r
Application:IHC-P
Positive cellular localization: Cytoplasm
Reactivity: Human
Host: Rabbit
Background
Succinate dehydrogenase (SDH) complex is a key respiratory enzyme composed of four subunits: SDHA, SDHB, SDHC and SDHD. Normal cells generally express SDHB in plasma, while abnormal cells lack SDHB expression.SDHB mutation can lead to tumors in chromaffin cells, causing a class of tumors called succinate dehydrogenase deficiency, including hereditary paraganglioma and hereditary pheochromocytoma, succinate dehydrogenase deficient renal cell carcinoma and succinate dehydrogenase deficient gastrointestinal stromal tumor (GIST).