TGF β Receptor I Monoclonal Antibody

Product Information
  • Cat:PA6100

  • Clone NO:YN01576m

  • Application:IHC-P

  • Positive cellular localization: Cytoplasm

  • Reactivity: Human

  • Host: Mouse

Background

TGF-β superfamily is a key regulator of cell proliferation, differentiation, development, morphogenesis and pathological mechanism. TGF- β transmits signals through three cell surface receptors: type I (RI), type II (RII) and type III (RIII). Type I and type II receptors are serine/threonine kinases that form heterolateral complexes. Under the stimulation of ligand binding, type II receptor and type I receptor form stable complex to phosphorylate and activate type I receptor kinase.

Pathological Antibodies