TIA-1

Background

TIA-1 (T cell intracytoplasmic antigen) is a cytotoxicity-related protein with a molecular weight of 15kDa, expressed by cytotoxic T cells. Studies have shown that 60-70% of anaplastic large cell lymphomas react with TIA-1. TIA-1 can also react with most large granular lymphoblastic leukemia, hepatosplenic T-cell lymphoma, intestinal T-cell lymphoma, NK like T-cell lymphoma, NK cell lymphoma, nasal T / NK cell lymphoma, subcutaneous t or NK phenotype cell lymphoma. TIA-1 was negative in all B-cell lymphoma, Hodgkin's lymphoma and lymphoblastic leukemia. TIA-1 is mainly used for the diagnosis of cytotoxic T cell and NK cell lymphoma.